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About This Simulation
Take advantage of the recent exciting research findings in the field, and try to develop a potential cure for heart failure. Will you be able to design a virus to help revert heart failure in patients?
Learning Objectives
- Explain the use of gene therapy for the treatment of heart failure
- Explain the causes of heart failure
- Design a viral mediated gene therapy approach
- Define "therapeutic gene"
- Describe the anatomy and function of the heart from a healthy person vs. a heart failure patient
- Produce replication defective recombinant adeno-associated virus (rAAV)
About This Simulation
Lab Techniques
- Electron microscopy
- Co-transfection of mammalian cells
- Viral vector production
Related Standards
- No direct alignment
- No direct alignment
- B.4 Medicine
Learn More About This Simulation
Does using viruses as a form of therapy sound like science fiction to you? This may come as a surprise, but it’s actually a technique on the rise used to deliver functional genes to patients. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how to equip them with therapeutic genes. Take advantage of the recent exciting research findings in the field, and try to develop a potential cure for heart failure. Will you be able to design a virus that can help to revert heart failure in patients?
Using viruses to cure heart failure
You will attend a seminar highlighting the causes and symptoms of heart failure, and will have to use gene therapy as a promising way for a treatment based on a particular gene. You will learn the principles behind the concept of gene therapy and pseudovirus production, and apply them to the present study case of heart failure.
Pseudovirus production and testing
You will perform a fitness test with mice to validate a gene as a therapeutic target for gene therapy. Next, they will have to produce the viral capsids containing the therapeutic gene through transfection of the Related plasmids and observe them through an electron microscope. Finally, the efficiency of the produced viruses will be tested on mice again. Since this is a virtual lab, no real animals will be harmed in this experiment, and results are available immediately compared to the expected 5 weeks of incubation.
Test your gene therapy treatment
Once you have designed your gene therapy treatment and produced your viruses containing a therapeutic gene, it will be time to test it on mice affected with heart failure. Will you be able to find a cure for this genetic condition?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
"I saw some of the students who clearly didn’t necessarily like sitting there reading a book discover they could turn on Labster and keep up with the rest of the class because it spoke to them.
Modesto City Schools
"Having something that's engaging for the students gives teachers that opportunity to breathe and get excited again. Because they're seeing the kids light up, they're seeing the kids engage with content."
Wenatchee Valley College
"The question always is, ‘Can we demonstrate that the students are meeting course outcomes?’ Check! We can do that.”
San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
FAQs
Find answers to frequently asked questions.
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Labster can be integrated within a school's LMS (Learning Management System), and students can access it like any other assignment in their LMS. If your Institution does not choose an LMS integration, students will log in to Labster's Course Manager once they have an account created. Your institution will decide the access method during the sales process.
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Labster simulations are created by real scientists and designed with unparalleled interactivity. Unlike point and click competitors, Labster simulations immerse students and encourage mastery through active learning.
Labster supports a wide range of courses at the high school and university level across fields in biology, chemistry and physics. Some simulations mimic lab procedures with high fidelity to train foundational skills, while others are meant to bring theory to life through interactive scenarios.