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About This Simulation
Check out how some vertebrates are able to regrow entire limbs and explore the cellular mechanisms behind tissue regeneration in cute axolotls using microscopy and fluorescent proteins.
Learning Objectives
- Understand that the ability to regenerate tissues varies throughout vertebrates
- Describe what a blastema is and the cell types that compose this structure
- Understand the concept of positional information in regenerative biology
About This Simulation
Lab Techniques
- Microscopy
- Fluorescent proteins
- Dissection
Related Standards
- No direct alignment
- No direct alignment
- Biology 1.1 Introduction to cells
Learn More About This Simulation
Regeneration sounds like a superpower, but some reptiles and amphibians are perfectly able to regrow entire parts of their bodies. In the Regeneration Biology simulation, you get to dissect axolotls and observe the cells responsible for the restoration of missing limbs under the microscope.
Grasp the cellular mechanisms behind tissue regeneration
You will join Dr. Prometheus in his research to learn why some wounds can regenerate and others cannot, and how it translates into different treatments in a medical ward. You will experiment with axolotls in the Regeneration Biology lab to discover the critical steps required for regeneration to occur and learn about the cellular particularities of the blastema.
Tissue analysis and fluorescent constructs
In the Regeneration Biology lab, you will be able to virtually dissect axolotls and observe the regeneration process in a few minutes instead of weeks. In that way, you can experiment with different conditions, for example suturing a wound, and immediately see how it affects the tissues – all without harming any real animals. Using a microscope, you will also analyze the tissue samples from a regenerating stump to identify the involved cell types. Finally, you will use fluorescent proteins to explore the concept of positional information and its importance in regenerative biology through the creation of mutant axolotls.
Apply the data from axolotls to humans
You will apply your newly acquired knowledge of regeneration biology to understand the current treatments for open wounds and the possibilities for the future of medicine.
Will you be able to figure out why humans cannot regenerate as well as some other vertebrates?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
"I saw some of the students who clearly didn’t necessarily like sitting there reading a book discover they could turn on Labster and keep up with the rest of the class because it spoke to them.
Modesto City Schools
"Having something that's engaging for the students gives teachers that opportunity to breathe and get excited again. Because they're seeing the kids light up, they're seeing the kids engage with content."
Wenatchee Valley College
"The question always is, ‘Can we demonstrate that the students are meeting course outcomes?’ Check! We can do that.”
San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
