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About This Simulation
Help a group of doctors in their search for the genetic cause of a rare disease by performing a genetic screening using C. elegans as the animal model.
Learning Objectives
- Explain the importance of C. elegans as an invertebrate model system in medical research
- Perform a forward genetic screen
- Use sequencing data to discover the genes of interest
About This Simulation
Lab Techniques
- Random mutagenesis
- Genetic screening
- Working with C. elegans
Related Standards
- No direct alignment
- No direct alignment
- No direct alignment
Learn More About This Simulation
A patient with a deformed head is examined at the hospital. He has been diagnosed with Saethre-Chotzen syndrome. In this simulation, you will learn how to use an invertebrate model system to perform a forward genetic screening and find out the cause of this rare disease.
Knowing your model organism
The experiments performed in this simulation are based on C. elegans, an invertebrate model system widely used to investigate genetic diseases. Using the microscope, you will learn about its life cycle and identify the different stages, as well as how to differentiate males from hermaphrodites.
Give a twist to your genetic screening using fluorescence
Despite mutations in the TWIST gene being associated with this rare disease, the doctors could not find any mutation in this gene in the patient. In order to investigate further, you will mutate your sample of C. elegans. They already carry the green fluorescent protein linked to the Twist protein so you can track the individuals carrying mutations under the fluorescence microscope throughout the experiment. You will be able to perform a complete genetic screening in this invertebrate model system in one-tenth of the time you would need in real life!
Discover what mutations are involved in the Saethre-Chotzen syndrome
You will analyze the initial cross progeny from breeding a mutated male worm with hermaphrodites and screen the subsequent F2 and F3 generations. During the process, you will understand the differences between dominant and recessive mutations, and you will be able to explore each plate with the different generations of this invertebrate model system as much as you want!
At the end of the screening, you will be able to discuss which mutations are related to the disease phenotype. Will you be able to find the mutated protein?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
"I saw some of the students who clearly didn’t necessarily like sitting there reading a book discover they could turn on Labster and keep up with the rest of the class because it spoke to them.
Modesto City Schools
"Having something that's engaging for the students gives teachers that opportunity to breathe and get excited again. Because they're seeing the kids light up, they're seeing the kids engage with content."
Wenatchee Valley College
"The question always is, ‘Can we demonstrate that the students are meeting course outcomes?’ Check! We can do that.”
San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
FAQs
Find answers to frequently asked questions.
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Labster can be integrated within a school's LMS (Learning Management System), and students can access it like any other assignment in their LMS. If your Institution does not choose an LMS integration, students will log in to Labster's Course Manager once they have an account created. Your institution will decide the access method during the sales process.
Labster is only available for purchase by faculty and administration at academic institutions. To procure Labster, simply reach out to us on our website. Schedule a demo, book a meeting to discuss pricing, start a free trial, or simply fill out our contact form.
Labster simulations are created by real scientists and designed with unparalleled interactivity. Unlike point and click competitors, Labster simulations immerse students and encourage mastery through active learning.
Labster supports a wide range of courses at the high school and university level across fields in biology, chemistry and physics. Some simulations mimic lab procedures with high fidelity to train foundational skills, while others are meant to bring theory to life through interactive scenarios.