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About This Simulation
Dissect chicken and mouse embryos to visualize and analyze embryonic development. Compare genetic results from the model organisms with the genetic laboratory results from a human case study to determine the cause and effect of Liebenberg Syndrome.
Learning Objectives
- Window a chicken egg
- Dissect a limb bud
- Identify different Hamilton-Hamburger stages of chick development
- Analyze Next Generation Sequencing data
About This Simulation
Lab Techniques
- Light microscopy
- Next Generation Sequencing
- Limb bud dissection
- Chicken egg windowing
Related Standards
- HS-LS4-1
- Topic 6.8: Biotechnology
- Biology Unit 3: Genetics
Learn More About This Simulation
What determines whether a body grows an arm or a leg?
In the Embryology simulation, you will learn how to window a chicken egg and decipher the Hamburger-Hamilton stages of chick embryonic development using a light microscope. Supplement your observations with Next Generation Sequencing of mice embryos to pinpoint the genes involved in limb development.
Investigate a family’s genetic condition
In this simulation, you will first uncover the basis of a patient’s inherited genetic condition. Begin by identifying common and specific genes involved in hindlimb and forelimb development using Next Generation Sequencing of mouse limb bud RNA. You will then make an educated hypothesis about which gene is mutated in Liebenberg Syndrome based on the phenotype.
Experiment with Embryonic Development
To understand and analyze the different stages of embryonic development, you will learn how to incubate chicken eggs and window them at different times to observe morphological changes. Observe the various stages of embryonic development by using a light microscope, and view and compare larger-than-life 3D models of chick embryos at different Hamburger-Hamilton stages of development.
Next, compare the morphological and genetic similarities between model organisms and human embryonic development: what are the evolutionary reasons for similarities between embryonic development in animals? To better understand these similarities, you will perform a mouse limb bud dissection in preparation for measuring the gene expression levels in different tissues throughout development. Analyze multiple types of Next Generation Sequencing data output to hypothesize the impact of over- or under-expression of different genes involved in limb development.
Compare Genetic Expression Levels
Use Next-Generation Sequencing to determine RNA expression levels of healthy subjects and predict the effects of incorrect gene expression levels on limb development. Will you be able to figure out which genetic mutations affect limb development in Liebenberg Syndrome?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
"I saw some of the students who clearly didn’t necessarily like sitting there reading a book discover they could turn on Labster and keep up with the rest of the class because it spoke to them.
Modesto City Schools
"Having something that's engaging for the students gives teachers that opportunity to breathe and get excited again. Because they're seeing the kids light up, they're seeing the kids engage with content."
Wenatchee Valley College
"The question always is, ‘Can we demonstrate that the students are meeting course outcomes?’ Check! We can do that.”
San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
FAQs
Find answers to frequently asked questions.
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Labster can be integrated within a school's LMS (Learning Management System), and students can access it like any other assignment in their LMS. If your Institution does not choose an LMS integration, students will log in to Labster's Course Manager once they have an account created. Your institution will decide the access method during the sales process.
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Labster supports a wide range of courses at the high school and university level across fields in biology, chemistry and physics. Some simulations mimic lab procedures with high fidelity to train foundational skills, while others are meant to bring theory to life through interactive scenarios.