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About This Simulation
Explore the structure of proteins and learn about the synthesis process inside the cells. Examine the protein sequence to understand the differences of protein synthesis in prokaryotes and eukaryotes.
Learning Objectives
- Understand the translation process from mRNA to amino acid
- Understand the post-translational modification
- Understand the protein synthesis processing in the ribosome
- Understand the primary, secondary, tertiary and quaternary structures of protein
- Understand the basic principles of mass spectrometry (MALDI-TOF)
About This Simulation
Lab Techniques
- Protein synthesis
- Mass spectrometry
Related Standards
- HS-LS1-1
- Unit 6: Gene Expression and Regulation
- Big Idea 2: Energetics
- 2.4 Proteins
- 2.7 DNA replication, transcription and translation
Learn More About This Simulation
In the Protein Synthesis lab, you will learn about the difference between protein synthesis in prokaryote (using E. coli) and eukaryote (using CHO cells).
Prepare recombinant Erythropoietin and use the mass spectrometer
Your first task in the lab will be to prepare recombinant Erythropoietin that is transfected into E. coli and CHO cells. The lab assistant will prepare the recombinant EPO and you will measure the mass to charge ratio using a mass spectrometer. Not sure how to handle the mass spectrometer? No worries! You can just take out your labpad and find an animated video to learn the basics.
Study the translation process from mRNA to amino acids
You will also learn about the translation process from mRNA to amino acids and how amino acids are assembled to proteins. A 3D animation is shown describing how triplets of codons are translated into amino acids, how these amino acids are joined together by peptide bonds creating a primary structure of protein, and furthermore, how the primary structure is folded into secondary, tertiary and quaternary structure.
Investigate doping in bike athletes
In the last part of the Protein Synthesis lab, you will use mass spectrometry and investigate if there are any athletes who are using rhEPO as a doping substance. You will do so by collaborating with the doping agent who collects urine samples in a large bicycle race.
Will you be able to detect if any of the athletes are using doping?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
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Lecturer in Human Physiology
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Modesto City Schools
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San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
FAQs
Find answers to frequently asked questions.
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